Searle healthNet/About/Products on the Market

Note: The chart below reflects the products currently sold by Searle in the United States. However, Searle is a global corporation, and in the future, information will be added on products marketed in other key countries.

cardiovascular | sleep | arthritis | women's health| FDA clearance now being sought

CARDIOVASCULAR

Aldactone®
(spironolactone)

Treatment of hypertension (high blood pressure) and edema (swelling due to fluid retention, which is often associated with congestive heart failure and kidney failure). Classification: ACE inhibitor.

Aldactazide®
(spironolactone/
hydrochlorothiazide)

Treatment of hypertension and edema. Classification: combination of an ACE inhibitor and diuretic.

Calan®
Calan® SR
(verapamil hydrochloride)

Calan: Treatment of angina (chest pain) and hypertension. CalanSR: Treatment of hypertension, with a sustained-relief formulation that allows once-a-day dosing. Classification: long-acting calcium channel blocker.

Covera-HS™
(verapamil hydrochloride)

Treatment of hypertension and angina. COER-24™ delivery system aligns treatment with the natural circadian rhythm of blood pressure and heart rate. Classification: long-acting calcium channel blocker.

Kerlone®
(betaxolol)

Treatment of hypertension. Classification: beta blocker.

Norpace®
Norpace® CR
(disopyramide phosphate)

Treatment of arrhythmia (irregular heart beat). Controlled-release (CR) formulation allows twice-a-day dosing.

Slow-Mag®
(magnesium chloride)

Dietary supplement that replenishes magnesium levels in the body. Available without a prescription.

SLEEP

Ambien®
(zolpidem tartrate) CIV

Short-term treatment of insomnia.

ARTHRITIS

Daypro®
(oxaprozin)

Treatment of the signs and symptoms of osteoarthritis and rheumatoid arthritis. Classification: nonsteroidal anti-inflammatory drug (NSAID).

Cytotec®
(misoprostol)
Prevention of gastric ulcers caused by use of nonsteroidal anti-inflammatory drugs (NSAIDs), the most common medications for treating arthritis.

WOMEN'S HEALTH

Flagyl®
(metronidazole)
Flagyl® 375
(metronidazole capsules)

Treatment of certain anaerobic bacterial infections, including trichomonas vaginalis, a common gynecologic infection. 375 mg dosage form allows medication to be taken twice a day rather than three times.

Demulen®
(ethynodiol diacetate with ethinyl estradiol)
Tri-Noryl®
Norinyl®
Brevicon®
(norethindrone and ethinyl estradiol)

Nor QD®
(norethindrone)
Genora®
Levora®
(levonorgestrel and ethinyl estradiol)

Oral contraceptives for the prevention of pregnancy.

Synarel®
(nafarelin acetate)

Nasal spray for the treatment of endometriosis, the excessive growth of tissue outside of the uterus, often causing pain and infertility.

Maxaquin®
(lomefloxacin hydrochloride)
Treatment of urinary tract infections, chronic bronchitis and certain other common infections.

FDA CLEARANCE NOW BEING SOUGHT

Arthrotec®
(diclofenac/misoprostol)

Treatment of Osteoarthritis and adult rheumatoid arthritis. Combines diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), with misoprostol, which helps protect against NSAID-induced gastric ulcers. New drug application filed with U.S. Food and Drug Administration December 1995.

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Aldactone® (spironolactone)	Treatment of hypertension (high blood pressure) and edema (swelling due to fluid retention, which is often associated with congestive heart failure and kidney failure). Classification: ACE inhibitor.
Aldactazide® (spironolactone/ hydrochlorothiazide)	Treatment of hypertension and edema. Classification: combination of an ACE inhibitor and diuretic.
Calan® Calan® SR (verapamil hydrochloride)	Calan: Treatment of angina (chest pain) and hypertension. CalanSR: Treatment of hypertension, with a sustained-relief formulation that allows once-a-day dosing. Classification: long-acting calcium channel blocker.
Covera-HS™ (verapamil hydrochloride)	Treatment of hypertension and angina. COER-24™ delivery system aligns treatment with the natural circadian rhythm of blood pressure and heart rate. Classification: long-acting calcium channel blocker.
Kerlone® (betaxolol)	Treatment of hypertension. Classification: beta blocker.
Norpace® Norpace® CR (disopyramide phosphate)	Treatment of arrhythmia (irregular heart beat). Controlled-release (CR) formulation allows twice-a-day dosing.
Slow-Mag® (magnesium chloride)	Dietary supplement that replenishes magnesium levels in the body. Available without a prescription.

Daypro® (oxaprozin)	Treatment of the signs and symptoms of osteoarthritis and rheumatoid arthritis. Classification: nonsteroidal anti-inflammatory drug (NSAID).
Cytotec® (misoprostol)	Prevention of gastric ulcers caused by use of nonsteroidal anti-inflammatory drugs (NSAIDs), the most common medications for treating arthritis.

Flagyl® (metronidazole) Flagyl® 375 (metronidazole capsules)	Treatment of certain anaerobic bacterial infections, including trichomonas vaginalis, a common gynecologic infection. 375 mg dosage form allows medication to be taken twice a day rather than three times.
Demulen® (ethynodiol diacetate with ethinyl estradiol) Tri-Noryl® Norinyl® Brevicon® (norethindrone and ethinyl estradiol) Nor QD® (norethindrone) Genora® Levora® (levonorgestrel and ethinyl estradiol)	Oral contraceptives for the prevention of pregnancy.
Synarel® (nafarelin acetate)	Nasal spray for the treatment of endometriosis, the excessive growth of tissue outside of the uterus, often causing pain and infertility.
Maxaquin® (lomefloxacin hydrochloride)	Treatment of urinary tract infections, chronic bronchitis and certain other common infections.